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Synthesis of stereoselective 1-indanone derivatives.
Ma, et al. have reported a procedure for the synthesis of 2-fluoro-1-indanones by tandem reaction of alkylidene beta-ketoesters in the presence of Cu(II) triflate and N-fluorobenzenesulfonimide . The use of a chiral Cu(II) catalyst afforded the tandem product in good yield with high enantioselectivity.
J. Nie, H.-W. Zhu, H.-F. Cui, M.-Q. Hua, J.-A, Ma, Org. Lett., 2007, 9, 3053.

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91st Canadian Chemistry Conference & Exhibition
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August 17 – 21, 2008
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